The LDL Hypothesis (BLA S2E4)

The LDL Hypothesis  (BLA S2E4)

Do you ever wonder why we think that LDL plays such a big role in atherosclerosis, and why we try to lower it? Well in this episode we dive deep into the landmark studies that paved the way for the LDL hypothesis.

00:00 - Start
00:23 - Introduction
01:02 - Importance
02:02 - LDL review
04:09 - Atherosclerosis Review
06:14 - History of LDL/lipid Research
09:14 - 3 types of supporting data
12:14 - Framingham Studies
13:31 - 4S Trial
14:34 - West of Scotland Study
15:24 - CARE Trial
16:37 - Heart Protection Study
17:03 - PROSPER Study
17:53 - PROVE IT - TIMI 22 Trial
19:03 - IDEAL Trial
20:12 - REVERSAL Trial
21:15 - ASTEROID Trial
22:18 - IMPROVE-IT
23:52 - DESCARTES Study
25:17 - OSLER 1/2 Trials
26:12 - ODYSSEY LONG-TERM Study
27:03 - GLAGOV Study
27:43 - LDL lowering and risk reduction meta analysis
28:41 - FOURIER Trial
29:12 - ODYSSEY OUTCOMES
29:52 - Further lowering LDL meta analysis
31:11 - CLEAR HARMONY Trial
32:23 - What is optimal LDL study
33:58 - Mendelian Randomization
36:22 - Putting it all together
38:43 - Summary


REFERENCES

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*Disclaimer* This video is for entertainment, education, and informational purposes only. The topics  discussed should not solely be used to diagnose, treat , or prevent any condition.  The information presented here was created with an evidence based approach, but you please keep in mind that science is always changing and at the time of listening to this there may some new data that makes this information incomplete or inaccurate. Always seek the advice of your personal physician or qualified health care provider for questions regarding any medical condition.